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The Gunners were beaten by Aston Villa and Bayern Munich and must avoid another defeat to keep their title hopes alive.
The game will be played at the Molineux with Paul Tierney as referee. Kick-off is 19:30 (GMT+1).
Here is how the two teams are lining up.
Arsenal XI: Raya; White, Saliba, Gabriel, Kiwior; Rice, Odegaard, Havertz; Saka, Trossard, Jesus.
Subs: Ramsdale, Hein, Tomiyasu, Zinchenko, Elneny, Partey, Smith Rowe, Vieira, Martinelli, Nketiah, Nelson, Jorginho
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